Searchable abstracts of presentations at key conferences in endocrinology

ea0029p118 | Adrenal medulla | ICEECE2012

Geranylgeraniols are essential for adrenal catecholamine secretion

Tachikawa E. , Kutsukake M. , Tamura K. , Yosie M. , Hossain M. , Taira H.

Introduction: Dolichols are isoprenoids, which are synthesized from acetyl-CoA via mevalonic acid, and they are known to be abundant in endocrine system. Adrenal medulla, which is not only an endocrine organ but also an organ derived from neural crest, secrets catecholamines via sodium and subsequent calcium influxes into the cells through nicotinic ACh receptor-operated cation channels and voltage-sensitive calcium channels, respectively, when the medulla is stimulated by ace...